Flourensia fiebrigii S.F. blake: A medicinal plant from the Argentinean highlands with potential use as anti-rheumatic and anti-inflammatory

Flourensia fiebrigii is a plant used in traditional medicine the Argentine Calchaquí Valley as purgative, expectorant, anti-rheumatic and anti-inflammatory. The aim of this study was to analyze macroscopic microscopic characteristics F. leaf stem, phytochemical composition leaves ethanolic extracts validate its use description stem carried out. Two (immersions tinctures) from were obtained. analysis UHPLC-OT-MS metabolome fingerprinting both performed. anti-inflammatory activities determined using enzymatic inhibition assays xanthine-oxidase (XOD), secretory phospholipase A2 (sPLA2) lipoxygenase (LOX). micrographic characters described allow botanical characterization species. showed high level phenolic compounds with similar chromatographic patterns. Forty-five identified based on including several sesquiterpenes, chalcones, flavonoids, isoflavonoids, lignan phenylpropanoids acids that have been for first time able inhibit XOD activity and, consequently, formation uric acid reactive oxygen species, primary cause diseases, such gouty arthritis (IC50 values 1.10–2.12 ?g/mL). Pro-inflammatory enzymes like sPLA2 LOX also inhibited by 22.00–2.20 ?g/mL) decreasing production inflammation mediators. present work validates medicinal through assays. presence chemical demonstrated properties supports bioactivity fiebrigii.